Clinical Trials: Advancing Narcolepsy & IH Research

Explore active studies that aim to improve care, discover new treatments, and elevate the voices of those living with Narcolepsy and IH. Your experience matters.

Clinical trials and research
What Are

Clinical trials are research studies that involve human participants and are designed to evaluate medical, surgical, or behavioral interventions. They are essential to advancing our understanding of how new treatments work — whether that’s a medication, a device (like a pacemaker), a therapy, or even a lifestyle change.

For people with narcolepsy or idiopathic hypersomnia, clinical trials help determine whether new options are safe, effective, and potentially more beneficial than current treatments. They also offer participants a chance to contribute to future breakthroughs that could improve the lives of others with the same condition.

Why Participate?

Clinical trials aren’t just about science — they’re about people. Participating gives you the opportunity to:

1

Access potential new treatments before they’re widely available

2

Contribute to critical research that may improve future care

3

Help researchers understand real-world impacts of sleep disorders

Current and Upcoming Clinical Studies Seeking Participants

Here are some of the clinical trials currently enrolling individuals with narcolepsy or idiopathic hypersomnia. Each study has different requirements and goals — be sure to review eligibility before applying.

Mayo Clinic

This is an observational study evaluating patients diagnosed with narcolepsy or idiopathic hypersomnia that have been prescribed a new/different hypersomnia treatment.

📄 [Click here for more info.]

Axsome Therapeutics, Inc.

SUNOSI® (Solriamfetol) Pregnancy Registry: An Observational Study on the Safety of Solriamfetol Exposure in Pregnant Women and Their Offspring.

📄 [Click here for more info.]

University of Utah

Imagery Rehearsal Therapy for the Treatment of Nightmares in Narcolepsy: A Pilot Randomized Controlled Trial.

📄 [Click here for more info.]

Boston Children’s Hospital

Focused on improving social and relationship health in adolescents with narcolepsy or IH.

📄 [Click here for more info.]

Stanford University

Safety, Convenience, and Tolerability of a Nightly Single Oral Dose of Extended-release Sodium Oxybate in Children.

📄 [Click here for more info.]

ORX750 Study – CRYSTAL-1 (Centessa Pharmaceuticals)

Investigating ORX750 in people with narcolepsy or idiopathic hypersomnia.

📄 [Click here for more info.]

Harmony Biosciences Management, Inc.

WAKIX® (Pitolisant) Pregnancy Registry: An Observational Study of the Safety of Pitolisant Exposure in Pregnant Women and Their Offspring.

📄 [Click here for more info.]

Unhide® Project

The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions.

📄 [Click here for more info.]

DynamicLight Study

The journey to understand narcolepsy is ongoing, and clinical research may provide a fresh start. By participating in a research study, we can work together to try to uncover new insights and drive progress for those living with narcolepsy with cataplexy.

📄 [Click here for more info.]

Know a Study We Should Share?

If you’re aware of a clinical trial, registry, or research initiative not listed here that may help others in the community, we’d love to hear from you. Please send us the link and a brief description so we can consider adding it.