1870’s – Syndrome first described 1930’s – Stimulant treatments 1950’s – Sleep-onset REM periods 1970’s – Canine model 1980’s – Association with immune related human leukocyte antigens (HLA) 2000’s – Discovery of canine gene and lack of hypocretin in human narcolepsy 2010’s – Autoimmune basis of narcolepsy 202?’s – Hypocretin agonists and prevention. 202? is of course the future and a goal for scientists worldwide to reach.